Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments.

Abstract

Apoptosis is a major determinant of the effectiveness of antitumor chemotherapy since most of the drugs used in cancer treatment provoke cell death by this process. We selected L1210/0.7R (7-fold) and L1210/3R (16-fold) murine leukemia cells resistant to cisplatin (CDDP) by adaptation of parental L1210/S cells to increasing drug concentration. L1210/0.7R… (More)

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@article{Canitrot1997DeficientAP, title={Deficient apoptotic process in cisplatin-resistant L1210 cells cannot account for the cellular response to various drug treatments.}, author={Yvan Canitrot and Philippe Frit and Bernard Salles}, journal={Biochemical and biophysical research communications}, year={1997}, volume={234 3}, pages={573-7} }