Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

  title={Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells},
  author={Claudia Friesen and Simone Fulda and K. M. Debatin},
The molecular mechanisms for sensitivity and resistance of tumor cells towards chemotherapy are only partially understood. In chemosensitive leukemias and solid tumors, anticancer drugs have been shown to induce apoptosis. We previously identified activation of the CD95 (APO-1/Fas) receptor/CD95 ligand (CD95/CD95-L) system as a key mechanism for drug-induced apoptosis. Here, we show that therapeutic concentrations of doxorubicin, methotrexate and cytarabine also induce apoptosis via activation… CONTINUE READING