Deficient Spindle Assembly Checkpoint in Multiple Myeloma

  title={Deficient Spindle Assembly Checkpoint in Multiple Myeloma},
  author={Elena D{\'i}az-Rodr{\'i}guez and Stela {\'A}lvarez-Fern{\'a}ndez and Xi Chen and Bruno Paiva and Ricardo L{\'o}pez-P{\'e}rez and Juan Luis Garc{\'i}a-Hern{\'a}ndez and Jes{\'u}s Fernando San Miguel and Atanasio Pandiella},
  booktitle={PloS one},
Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and chromosomal gains and losses. In fact, a singular characteristic differentiating MM from other hematological malignancies is the presence of a high degree of aneuploidies. As chromosomal abnormalities can be generated by alterations in the spindle… CONTINUE READING
Highly Cited
This paper has 42 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 5 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 20 extracted citations

Chromosomal instability and acquired drug resistance in multiple myeloma

Oncotarget • 2017
View 9 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 41 references

Cancer statistics , 2007

MS Raab, K Podar, I Breitkreutz, PG Richardson, KC Anderson
Lancet • 2009

Centrosomes and myeloma; aneuploidy and proliferation.

Environmental and molecular mutagenesis • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…