Deficient Spindle Assembly Checkpoint in Multiple Myeloma

@inproceedings{DazRodrguez2011DeficientSA,
  title={Deficient Spindle Assembly Checkpoint in Multiple Myeloma},
  author={Elena D{\'i}az-Rodr{\'i}guez and Stela {\'A}lvarez-Fern{\'a}ndez and Xi Chen and Bruno Paiva and Ricardo L{\'o}pez-P{\'e}rez and Juan Luis Garc{\'i}a-Hern{\'a}ndez and Jes{\'u}s Fernando San Miguel and Atanasio Pandiella},
  booktitle={PloS one},
  year={2011}
}
Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and chromosomal gains and losses. In fact, a singular characteristic differentiating MM from other hematological malignancies is the presence of a high degree of aneuploidies. As chromosomal abnormalities can be generated by alterations in the spindle… CONTINUE READING
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