Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

@article{Kwak2004DeficientRE,
  title={Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis},
  author={Shin Kwak and Yukio Kawahara},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={83},
  pages={110-120}
}
One plausible hypothesis for selective neuronal death in sporadic amyotropic lateral sclerosis (ALS) is excitotoxicity mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors, which are a subtype of ionotropic glutamate receptors. The Ca2+ conductance of AMPA receptors differs markedly depending on whether the GluR2 (or GluR-B) subunit is a component of the receptor. The properties of GluR2 are generated posttranscriptionally by RNA editing at the Q/R site in the putative… 
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