Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.

Abstract

Neonates respond suboptimally to many vaccines. The reasons for this defect are unclear, but suboptimal antigen presentation by dendritic cells has been suggested as one possibility. In this report we describe an in vitro system that allows the generation of large numbers of resting murine neonatal dendritic cells facilitating their study. Using this system… (More)

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