Deficient IFN alpha production in hairy cell leukemia.

  title={Deficient IFN alpha production in hairy cell leukemia.},
  author={Franz Porzsolt and R Janik and Gerhard Heil and O Brudler and Aruna Raghavachar and Sibylle Scholz and U. Papendick and Hermann Heimpel},
  volume={52 3},
Since the application of low doses of IFN-alpha is necessary to maintain remissions in Hairy Cell Leukemia (HCL) it is of interest whether peripheral blood mononuclear cells (MNC) of HCL patients can be induced in vitro to produce IFN-alpha. 9 patients suffering from advanced HCL were included in the study. The diagnoses were confirmed by characteristic findings in peripheral blood and bone marrow biopsies. For IFN treatment we initially used natural IFN-alpha (Bioferon) and switched later to… CONTINUE READING