Deficient Herpes Simplex Virus-Induced Interferon-α Production by Blood Leukocytes of Preterm and Term Newborn Infants

@article{Cederblad1990DeficientHS,
  title={Deficient Herpes Simplex Virus-Induced Interferon-α Production by Blood Leukocytes of Preterm and Term Newborn Infants},
  author={Britta Cederblad and Tomas Riesenfeld and Gunnar V. Alm},
  journal={Pediatric Research},
  year={1990},
  volume={27},
  pages={7-10}
}
ABSTRACT: The ability of peripheral blood mononuclear cells (PBMC) from newborn infants, gestational age 24-42 wk, to produce interferon-α (IFN-α) on the first day after birth was studied in vitro. Human amnion cells (WISH) coated with herpes simplex virus type I and fixed by glutaraldehyde were used as IFN-α inducers. Individual IFN-α producing cells (IPC) among PBMC were determined by an immunoplaque assay. The frequency of IPC was low in all premature (≤36 wk) infants (median 0.3 IPC/104… CONTINUE READING