Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis

Abstract

The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6−/− mice did not, however, suffer… (More)
DOI: 10.1038/84667

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