Deficiency of voltage-gated proton channel Hv1 attenuates streptozotocin-induced β-cell damage.

Abstract

Reactive oxygen species (ROS) impairs pancreatic β-cells and plays an important role in development of diabetes. Streptozotocin (STZ) can lead to β-cell dysfunction via inducing ROS production. The voltage-gated proton channel Hv1 contributes a majority of the charge compensation required for ROS production. Here, we investigated the effects of Hv1 on STZ… (More)
DOI: 10.1016/j.bbrc.2018.03.092

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