Deficiency of vitamin E and selenium enhances calcium-independent phospholipase A2 activity in rat lung and liver.

@article{Kuo1995DeficiencyOV,
  title={Deficiency of vitamin E and selenium enhances calcium-independent phospholipase A2 activity in rat lung and liver.},
  author={Chin Fang Kuo and Shuijie Cheng and John R. Burgess},
  journal={The Journal of nutrition},
  year={1995},
  volume={125 6},
  pages={1419-29}
}
Conditions promoting oxidative stress, which is implicated in many diseases, activate phospholipases A2, a family of enzymes central to phospholipid metabolism and signal transduction. Little is known about isozyme specificity with respect to this activation process. Accordingly, a dietary deficiency model known to induce oxidative stress was used to investigate phospholipase A2 isozyme activity in rat tissues. Long-Evans hooded rats were fed purified diets for 6 wk with or without the addition… CONTINUE READING
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