Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.

Abstract

BACKGROUND Chronic hypoxia results in the development of pulmonary hypertension and subsequent right heart failure. A role of the plasminogen system in the pathogenesis of pulmonary hypertension and pulmonary vascular remodeling has been suggested. METHODS AND RESULTS Mice with targeted deficiency of the gene encoding tissue-type plasminogen activator (t… (More)

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@article{Levi2001DeficiencyOU, title={Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice.}, author={Miriam Levi and Leon M. G. Moons and A Bouch{\'e} and S. D. Shapiro and D. Collen and Peter Carmeliet}, journal={Circulation}, year={2001}, volume={103 15}, pages={2014-20} }