Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.

@article{Westrick2001DeficiencyOT,
  title={Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice.},
  author={Randal J. Westrick and Peter F. Bodary and Z Xu and Ying Chun Shen and George J. Broze and Daniel T. Eitzman},
  journal={Circulation},
  year={2001},
  volume={103 25},
  pages={3044-6}
}
BACKGROUND Tissue factor initiates blood coagulation after atherosclerotic plaque disruption. Tissue factor pathway inhibitor (TFPI) inhibits tissue factor activity and may reduce thrombus formation in this setting. We evaluated the effect of heterozygous TFPI deficiency on the development of atherosclerosis and thrombosis in atherosclerosis-prone mice. METHODS AND RESULTS Mice with a combined heterozygous TFPI deficiency and homozygous apolipoprotein E deficiency (TFPI(+/-)/apoE(-/-)) were… CONTINUE READING
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