Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.

@article{Fontalba2007DeficiencyOT,
  title={Deficiency of the NF-kappaB inhibitor caspase activating and recruitment domain 8 in patients with rheumatoid arthritis is associated with disease severity.},
  author={Ana Fontalba and V{\'i}ctor Mart{\'i}nez-Taboada and Olga Guti{\'e}rrez and Carlos Pipa{\'o}n and Natividad Benito and Alejandro Balsa and Ricardo Blanco and Jos{\'e} Luis Fern{\'a}ndez-Luna},
  journal={Journal of immunology},
  year={2007},
  volume={179 7},
  pages={4867-73}
}
Caspase activating and recruitment domain 8 (CARD8) potently inhibits NF-kappaB signaling, which plays a key role in inflammation, and may contribute to avoid a pathologic activation of NF-kappaB; however, the transcriptional mechanisms regulating CARD8 expression and the relevance of this protein in inflammatory diseases are poorly understood. We found a NF-kappaB-binding element within the human CARD8 promoter that was required for transcriptional activity in response to TNF-alpha and the p65… CONTINUE READING

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