Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.

  title={Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse.},
  author={Hiroki Nakahara and Esteban C Gabazza and Hajime Fujimoto and Yoichi Nishii and Corina Nayade D'Alessandro-Gabazza and Nelson E Bruno and Takehiro Takagi and Tatsuya Hayashi and Junko Maruyama and Kazuo Maruyama and Kyoko Imanaka-Yoshida and Koji A. O. Suzuki and Toshimichi Yoshida and Yukihiko Adachi and Osamu Taguchi},
  journal={European journal of immunology},
  volume={36 12},
Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma. However, the exact function of TN-C in the pathogenesis of lung inflammation remains unclear. In the present study, we compared the degree of bronchial asthma in wild-type and TN-C-deficient (-/-) BALB/c mice. Bronchial asthma was induced by sensitization and challenge with ovalbumin. Littermates treated with saline were used as… CONTINUE READING
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