Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes.

@article{Ritov2005DeficiencyOS,
  title={Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes.},
  author={Vladimir B. Ritov and Elizabeth V. Menshikova and Jing He and R. Ferrell and Bret H. Goodpaster and David E Kelley},
  journal={Diabetes},
  year={2005},
  volume={54 1},
  pages={
          8-14
        }
}
The current study addresses a novel hypothesis of subcellular distribution of mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus lateralis muscle was obtained by percutaneous biopsy from 11 volunteers with type 2 diabetes; 12 age-, sex-, and weight-matched obese sedentary nondiabetic volunteers; and 8 lean volunteers. Subsarcolemmal and intermyofibrillar mitochondrial fractions were isolated by differential centrifugation and digestion techniques. Overall electron transport… CONTINUE READING

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