Deficiency of pulmonary Valpha24 Vbeta11 natural killer T cells in corticosteroid-naïve sarcoidosis patients.

@article{Koroec2010DeficiencyOP,
  title={Deficiency of pulmonary Valpha24 Vbeta11 natural killer T cells in corticosteroid-na{\"i}ve sarcoidosis patients.},
  author={P Koro{\vs}ec and M Rijavec and Mira {\vS}ilar and Izidor Kern and Mitja Ko{\vs}nik and Katarina Osolnik},
  journal={Respiratory medicine},
  year={2010},
  volume={104 4},
  pages={571-7}
}
Invariant natural killer T (NKT) cells might contribute to the amplified and prolonged T-cell immune response that characterizes sarcoidosis. Therefore, we want to investigate the frequency and distribution of pulmonary invariant NKT cells in corticosteroid-naïve patients with sarcoidosis. We used multi-parameter flow cytometry with antibodies against CD3, CD4, CD8, CD14, CD19, CD45, CD16/56, TCR Valpha24, and TCR Vbeta11, on bronchoalveolar lavage fluid (BALF), to examine the frequency and… CONTINUE READING