Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

@article{Strooper1998DeficiencyOP,
  title={Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein},
  author={Bart de Strooper and Paul Saftig and Katleen Craessaerts and Hugo Marcel Johan Vanderstichele and Gundula Guhde and Wim Annaert and Kurt von Figura and F. Van Leuven},
  journal={Nature},
  year={1998},
  volume={391},
  pages={387-390}
}
Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective increase in the production of the amyloidogenic peptide amyloid-β(1–42) by proteolytic processing of the amyloid precursor protein (APP). Here we investigate whether PS1 is also involved in normal APP processing in neuronal cultures derived from PS1-deficient mouse embryos. Cleavage by α- and β-secretase of the extracellular domain of APP was not affected by the absence… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 516 extracted citations

Similar Papers

Loading similar papers…