Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

Abstract

Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's disease. They result in a selective increase in the production of the amyloidogenic peptide amyloid-beta(1-42) by proteolytic processing of the amyloid precursor protein (APP). Here we investigate whether PS1 is also involved in normal APP processing in neuronal… (More)

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Cite this paper

@article{Strooper1998DeficiencyOP, title={Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.}, author={Bart De Strooper and Paul Saftig and Katleen Craessaerts and Hugo Marcel Johan Vanderstichele and G Guhde and Wim G. Annaert and Kurt von Figura and Fred van Leuven}, journal={Nature}, year={1998}, volume={391 6665}, pages={387-90} }