Deficiency of platelet-derived growth factor receptor-α-positive cells in Hirschsprung's disease colon.

@article{Odonnell2016DeficiencyOP,
  title={Deficiency of platelet-derived growth factor receptor-$\alpha$-positive cells in Hirschsprung's disease colon.},
  author={A. O'donnell and D. Coyle and P. Puri},
  journal={World journal of gastroenterology},
  year={2016},
  volume={22 12},
  pages={
          3335-40
        }
}
AIM To investigate whether the expression of platelet-derived growth factor receptor-α-positive (PDGFRα(+))-cells is altered in Hirschsprung's disease (HD). METHODS HD tissue specimens (n = 10) were collected at the time of pull-through surgery, while colonic control samples were obtained at the time of colostomy closure in patients with imperforate anus (n = 10). Immunolabelling of PDGFRα(+)-cells was visualized using confocal microscopy to assess the distribution of these cells, while… Expand
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