Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma.

  title={Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma.},
  author={Diana M. Stafforini and Toshio Numao and A. Tsodikov and D L Vaitkus and Toru Fukuda and Naoko Watanabe and Naoto Fueki and Thomas M McIntyre and Guy A. Zimmerman and Susumu Makino and Stephen M. Prescott},
  journal={The Journal of clinical investigation},
  volume={103 7},
Asthma, a family of airway disorders characterized by airway inflammation, has an increasing incidence worldwide. Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma. Its proinflammatory actions are antagonized by PAF acetylhydrolase. A missense mutation (V279F) in the PAF acetylhydrolase gene results in the complete loss of activity, which occurs in 4% of the Japanese population. We asked if PAF acetylhydrolase deficiency correlates with the incidence and severity… CONTINUE READING


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