Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.

@article{Harada2013DeficiencyOP,
  title={Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.},
  author={Harumi Harada and Eiji Warabi and Taizo Matsuki and Toru Yanagawa and Koutaroh Okada and Junya Uwayama and Akira Ikeda and Kazuhiro Nakaso and Kyoko Kirii and Noriko Noguchi and Hiroki Bukawa and Richard C.M. Siow and Giovanni E. Mann and Junichi Shoda and Tsuyoshi Ishii and Takeshi Sakurai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 37},
  pages={
          14767-77
        }
}
The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that these mice show hyperphagia. Restriction of food to the amount eaten by wild-type mice prevented excess… CONTINUE READING
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