Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.

@article{Komori2014DeficiencyOO,
  title={Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.},
  author={Tadasuke Komori and Minoru Tanaka and Emiko Senba and Atsushi Miyajima and Yoshihiro Morikawa},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 20},
  pages={
          13821-37
        }
}
Oncostatin M (OSM) belongs to the IL-6 family of cytokines and has diverse biological effects, including the modulation of inflammatory responses. In the present study we analyzed the roles of OSM signaling in obesity and related metabolic disorders. Under a high-fat diet condition, OSM receptor β subunit-deficient (OSMRβ(-/-)) mice exhibited increases in body weight and food intake compared with those observed in WT mice. In addition, adipose tissue inflammation, insulin resistance, and… CONTINUE READING
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Metabolic Disorders in OSMR -deficient Mice 13836 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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  • MAY 16,
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