Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.

@article{Wang2011DeficiencyOL,
  title={Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.},
  author={Hong Wang and Giuseppe Astarita and Matthew D. Taussig and Kalyani G Bharadwaj and Nicholas V DiPatrizio and Klaus-Armin Nave and Daniele Piomelli and Ira J Goldberg and Robert H Eckel},
  journal={Cell metabolism},
  year={2011},
  volume={13 1},
  pages={105-13}
}
Free fatty acids (FFAs) suppress appetite when injected into the hypothalamus. To examine whether lipoprotein lipase (LPL), a serine hydrolase that releases FFAs from circulating triglyceride (TG)-rich lipoproteins, might contribute to FFA-mediated signaling in the brain, we created neuron-specific LPL-deficient mice. Homozygous mutant (NEXLPL-/-) mice were hyperphagic and became obese by 16 weeks of age. These traits were accompanied by elevations in the hypothalamic orexigenic neuropeptides… CONTINUE READING
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