Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.

@article{Xia2001DeficiencyOH,
  title={Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining.},
  author={Fen Xia and Danielle G Taghian and Jeffrey S DeFrank and Zhimin Zeng and Henning Willers and George Iliakis and Simon N Powell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 15},
  pages={8644-9}
}
Carriers of BRCA2 germline mutations are at high risk to develop early-onset breast cancer. The underlying mechanisms of how BRCA2 inactivation predisposes to malignant transformation have not been established. Here, we provide direct functional evidence that human BRCA2 promotes homologous recombination (HR), which comprises one major pathway of DNA double-strand break repair. We found that up-regulated HR after transfection of wild-type (wt) BRCA2 into a human tumor line with mutant BRCA2 was… CONTINUE READING
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Radiobiology for the Radiologist (Lippincott, Philadelphia)

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