Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice.

@article{Beer2014DeficiencyOE,
  title={Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice.},
  author={Marcielle de Beer and Joanne M. Wroblewski and Victoria J P Noffsinger and Debra L. Rateri and Deborah A. Howatt and Anju Balakrishnan and Ailing Ji and Preetha Shridas and Joel C. Thompson and Deneys R. van der Westhuyzen and Lisa R. Tannock and Alan Daugherty and Nancy Ridgeway Webb and Frederick C. de Beer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2014},
  volume={34 2},
  pages={
          255-61
        }
}
OBJECTIVE Although elevated plasma concentrations of serum amyloid A (SAA) are associated strongly with increased risk for atherosclerotic cardiovascular disease in humans, the role of SAA in the pathogenesis of lesion formation remains obscure. Our goal was to determine the impact of SAA deficiency on atherosclerosis in hypercholesterolemic mice. APPROACH AND RESULTS Apolipoprotein E-deficient (apoE(-/-)) mice, either wild type or deficient in both major acute phase SAA isoforms, SAA1.1 and… CONTINUE READING
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