Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice.

@article{Akyrek2010DeficiencyOC,
  title={Deficiency of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 accelerates atherogenesis in apolipoprotein E-deficient mice.},
  author={Levent M. Aky{\"u}rek and Manfred Boehm and Michelle Olive and Alex-Xianghua Zhou and Hong San and Elizabeth G. Nabel},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={396 2},
  pages={359-63}
}
Cyclin-dependent kinase inhibitors, p21(Cip1) and p27(Kip1), are upregulated during vascular cell proliferation and negatively regulate growth of vascular cells. We hypothesized that absence of either p21(Cip1) or p27(Kip1) in apolipoprotein E (apoE)-deficiency may increase atherosclerotic plaque formation. Compared to apoE(-/-) aortae, both apoE(-/-)/p21(-/-) and apoE(-/-)/p27(-/-) aortae exhibited significantly more atherosclerotic plaque following a high-cholesterol regimen. This increase… CONTINUE READING