Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.

@article{Kamura1992DeficiencyOC,
  title={Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon III.},
  author={Toshiharu Kamura and Takashi Okamura and Masahiro Murakawa and Hiroko Tsuda and Takanori Teshima and T Tsunefumi Shibuya and M. D. N. Harada and Yoshiyuki Niho},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 2},
  pages={315-9}
}
A congenital deficiency of the coagulation Factor XIII A subunit (F XIII A) is a rare autosomal recessive disorder that is characterized by a life-long bleeding tendency complicated by a difficulty in healing. Thus far, no molecular genetic analysis of this disorder has been reported. In this study, we demonstrate the molecular abnormalities in a family with this disorder. We performed Northern blot analysis of peripheral blood monocytes obtained from the propositus and found a 4-kb single band… CONTINUE READING