Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis.

  title={Deficiency of caveolin-1 in Apc(min/+) mice promotes colorectal tumorigenesis.},
  author={Teresa Friedrich and Birgit Richter and Timo Gaiser and Christel Weiss and K. Janssen and Henrik Einwaechter and Roland M Schmid and Matthias P. A. Ebert and Elke Burgermeister},
  volume={34 9},
Caveolin-1 (Cav1), a scaffold protein of membrane caveolae and coactivator of peroxisome proliferator-activated receptor gamma (PPARg), inhibits oncogenic signaling through Ras and wingless. However, the in vivo role of Cav1 in colorectal cancer (CRC) remained unknown. To test whether loss of Cav1 accelerates tumorigenesis, we generated a novel mouse model of CRC by crossing C57BL/6 Apc(min/+) with B6129 Cav1 knockout (Cav1-/-) mice. Apc(min/+) Cav1-/- mice developed large, microinvasive and… CONTINUE READING
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