Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.

@article{Iizuka2006DeficiencyOC,
  title={Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.},
  author={Katsumi Iizuka and Bonnie Miller and Kosaku Uyeda},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 2},
  pages={
          E358-64
        }
}
The transcription factor carbohydrate response element-binding protein (ChREBP) mediates insulin-independent, glucose-stimulated gene expression of multiple liver enzymes responsible for converting excess carbohydrate to fatty acids for long-term storage. To investigate ChREBP's role in the development of obesity and obesity-associated metabolic dysregulation, ChREBP-deficient mice were intercrossed with ob/ob mice. As a result of deficient leptin expression, ob/ob mice overeat, become obese… CONTINUE READING

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