Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis.

@article{Bhattacharya2014DeficiencyOA,
  title={Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis.},
  author={Abhisek Bhattacharya and Xyanthine Parillon and Shenyan Zeng and Shuhua Han and N Tony Eissa},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 38},
  pages={26525-32}
}
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) in the immune system. DCs present antigens to CD8 and CD4 T cells in the context of class I or II MHC. Recent evidence suggests that autophagy, a conserved intracellular degradation pathway, regulates class II antigen presentation. In vitro studies have shown that deletion of autophagy-related genes reduced antigen presentation by APCs to CD4 T cells. In vivo studies confirmed these findings in the context of infectious… CONTINUE READING
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