Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.

@article{Pangburn1983DeficiencyOA,
  title={Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria.},
  author={Michael K. Pangburn and Robert D Schreiber and Hans J. Mueller-Eberhard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 17},
  pages={
          5430-4
        }
}
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia in which the erythrocytes are abnormally sensitive to lysis by complement. A functional deficiency of membrane-associated complement regulators has been demonstrated on PNH erythrocytes. The two factor H-like proteins, the C3b receptor (CR1) and the decay-accelerating factor (DAF), were isolated from normal human erythrocytes, and specific antisera were prepared. Selective inhibition of the two proteins on normal… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 70 CITATIONS

Similar Papers

Loading similar papers…