Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes

@article{Leibowitz2010DeficiencyOA,
  title={Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes},
  author={Michael S. Leibowitz and Pedro A. Andrade Filho and Soldano Ferrone and Robert L Ferris},
  journal={Cancer Immunology, Immunotherapy},
  year={2010},
  volume={60},
  pages={525-535}
}
Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM component upregulation by interferon gamma (IFN-γ) restores SCCHN cell recognition and susceptibility to lysis by CTL, but the mechanism underlying TAP1/2 downregulation in SCCHN cells is not known… CONTINUE READING