Deficiency of acetylcholine receptors in a case of end-plate acetylcholinesterase deficiency: a histochemical investigation.

@article{Jennekens1992DeficiencyOA,
  title={Deficiency of acetylcholine receptors in a case of end-plate acetylcholinesterase deficiency: a histochemical investigation.},
  author={Frans G. I. Jennekens and L. F. G. M. Hesselmans and Henk Veldman and Ernst N. H. Jansen and Frank Spaans and Peter Molenaar},
  journal={Muscle & nerve},
  year={1992},
  volume={15 1},
  pages={63-72}
}
A young boy is described who, since early infancy, suffered from weakness of predominantly proximal limb muscles. Electromyography revealed impairment of neuromuscular transmission. There were no antibodies against acetylcholine receptors. The amplitude of miniature end-plate potentials was reduced. Neuromuscular junctions showed somewhat coarse postsynaptic junctional folds and degeneration products in the synaptic clefts and in postsynaptic areas. Using qualitative and semiquantitative… CONTINUE READING