Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle

@article{Ervasti1990DeficiencyOA,
  title={Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle},
  author={James M. Ervasti and Kay Ohlendieck and Steven D. Kahl and Mitchell G. Gaver and Kevin P Campbell},
  journal={Nature},
  year={1990},
  volume={345},
  pages={315-319}
}
Dystrophin, the protein encoded by the Duchenne muscular dystrophy (DMD) gene, exists in a large oligomeric complex. We show here that four glycoproteins are integral components of the dystrophin complex and that the concentration of one of these is greatly reduced in DMD patients. Thus, the absence of dystrophin may lead to the loss of a dystrophin-associated glycoprotein, and the reduction in this glycoprotein may be one of the first stages of the molecular pathogenesis of muscular dystrophy. 
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Biochim. biophys

  • N Alloislo
  • Acta 816,
  • 1985

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