Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance

@article{Luan2009DeficiencyOA,
  title={Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance},
  author={Bing Luan and Jian Zhao and Haiya Wu and Baoyu Duan and Guangwen Shu and Xiaoying Wang and Dangsheng Li and Weiping Jia and Jiuhong Kang and Gang Pei},
  journal={Nature},
  year={2009},
  volume={457},
  pages={1146-1149}
}
Insulin resistance, a hallmark of type 2 diabetes, is a defect of insulin in stimulating insulin receptor signalling, which has become one of the most serious public health threats. Upon stimulation by insulin, insulin receptor recruits and phosphorylates insulin receptor substrate proteins, leading to activation of the phosphatidylinositol-3-OH kinase (PI(3)K)–Akt pathway. Activated Akt phosphorylates downstream kinases and transcription factors, thus mediating most of the metabolic actions of… CONTINUE READING

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