Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice.


BACKGROUND AND AIMS SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human cancers. More recently, it has been shown to be upregulated in human gastric and colorectal cancer. We therefore wished to address the functional importance of SPARC upregulation to intestinal… (More)
DOI: 10.1136/gut.2006.116921


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