Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.

@article{Katagiri2011DeficiencyOR,
  title={Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.},
  author={Koko Katagiri and Yoshihiro Ueda and Takashi Tomiyama and Kaneki Yasuda and Yoshinobu Toda and Susumu Ikehara and Keiichi I Nakayama and Tatsuo Kinashi},
  journal={Immunity},
  year={2011},
  volume={34 1},
  pages={24-38}
}
RAPL (an alternative spliced form of Rassf5) is a critical Ras-related protein1 (Rap1) effector that regulates lymphocyte adhesion. Here, we have shown that in addition to this previously described function, RAPL also negatively controls lymphocyte proliferation and prevents autoimmunity and lymphoma. RAPL-deficient mice experienced age-related lupus-like glomerulonephritis and developed B cell lymphomas. RAPL-deficient lymphocytes showed hyperproliferation by enhanced S phase entry after… CONTINUE READING