Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.

@article{Katagiri2011DeficiencyOR,
  title={Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.},
  author={K. Katagiri and Y. Ueda and T. Tomiyama and K. Yasuda and Y. Toda and S. Ikehara and K. Nakayama and T. Kinashi},
  journal={Immunity},
  year={2011},
  volume={34 1},
  pages={
          24-38
        }
}
  • K. Katagiri, Y. Ueda, +5 authors T. Kinashi
  • Published 2011
  • Medicine, Biology
  • Immunity
  • RAPL (an alternative spliced form of Rassf5) is a critical Ras-related protein1 (Rap1) effector that regulates lymphocyte adhesion. Here, we have shown that in addition to this previously described function, RAPL also negatively controls lymphocyte proliferation and prevents autoimmunity and lymphoma. RAPL-deficient mice experienced age-related lupus-like glomerulonephritis and developed B cell lymphomas. RAPL-deficient lymphocytes showed hyperproliferation by enhanced S phase entry after… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 48 REFERENCES
    Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas.
    • 30
    The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
    • 353
    • Open Access
    Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.
    • 203
    • Open Access
    Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells
    • 32
    • Open Access
    IL-7 promotes T cell proliferation through destabilization of p27Kip1
    • 86
    • Open Access
    p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
    • 163
    Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
    • 201