Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity

@inproceedings{Satoh2015DeficiencyOP,
  title={Deficiency of Prdm13, a dorsomedial hypothalamus-enriched gene, mimics age-associated changes in sleep quality and adiposity},
  author={Akiko Satoh and Cynthia S Brace and Nick Rensing and Shin-ichiro Imai},
  booktitle={Aging cell},
  year={2015}
}
  • Akiko Satoh, Cynthia S Brace, +1 author Shin-ichiro Imai
  • Published in Aging cell 2015
  • Medicine, Biology
  • The dorsomedial hypothalamus (DMH) controls a number of essential physiological responses. We have demonstrated that the DMH plays an important role in the regulation of mammalian aging and longevity. To further dissect the molecular basis of the DMH function, we conducted microarray-based gene expression profiling with total RNA from laser-microdissected hypothalamic nuclei and tried to find the genes highly and selectively expressed in the DMH. We found neuropeptide VF precursor (Npvf), PR… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    2
    Twitter Mentions

    Citations

    Publications citing this paper.
    SHOWING 1-9 OF 9 CITATIONS

    It takes two to tango: NAD+ and sirtuins in aging/longevity control

    VIEW 1 EXCERPT
    CITES BACKGROUND

    The Multifaceted Roles of PRDM16: Adipose Biology and Beyond

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 34 REFERENCES

    Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain.

    VIEW 3 EXCERPTS
    HIGHLY INFLUENTIAL

    Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus.

    VIEW 5 EXCERPTS
    HIGHLY INFLUENTIAL

    SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.

    VIEW 5 EXCERPTS

    Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus.

    VIEW 14 EXCERPTS
    HIGHLY INFLUENTIAL

    Calorie restriction and sirtuins revisited.

    VIEW 2 EXCERPTS