Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice

  title={Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice},
  author={Mark C. Blaser and Kuiru Wei and Rachel L. E. Adams and Yu-Qing Zhou and Laura-lee Caruso and Zahra Mirzaei and Alan Y L Lam and R Tam and Hangjun Zhang and Scott P. Heximer and R. Mark Henkelman and Craig A. Simmons},
  journal={Circulation Research},
Rationale: Aortic valve disease is a cell-mediated process without effective pharmacotherapy. [] Key Result Myofibrogenesis in cultured Npr2+/− fibroblasts was insensitive to CNP treatment, whereas aged Npr2+/− and Npr2+/−;Ldlr−/− mice developed cardiac dysfunction and ventricular fibrosis.

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  • P. OliverJ. Fox N. Maeda
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
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