Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

@inproceedings{Myre2011DeficiencyOH,
  title={Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum},
  author={Michael A. Myre and Amanda L. Lumsden and Morgan Nicole Thompson and Wilma Wasco and Marcy E. MacDonald and James F. Gusella},
  booktitle={PLoS genetics},
  year={2011}
}
Huntingtin is a large HEAT repeat protein first identified in humans, where a polyglutamine tract expansion near the amino terminus causes a gain-of-function mechanism that leads to selective neuronal loss in Huntington's disease (HD). Genetic evidence in humans and knock-in mouse models suggests that this gain-of-function involves an increase or deregulation of some aspect of huntingtin's normal function(s), which remains poorly understood. As huntingtin shows evolutionary conservation, a… CONTINUE READING

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