Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice.

@article{Chaudhari2015DeficiencyOH,
  title={Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice.},
  author={Sweena M. Chaudhari and Judith C. Sluimer and Miriam Koch and Thomas Theelen and Helga D Manthey and Martin Busch and Celia Caballero-Franco and Frederick Vogel and Cl{\'e}ment Cochain and Jaroslav Pelisek and Mat J. A. P. Daemen and Manfred B Lutz and Agnes G{\"o}rlach and Stephan Kissler and Heike M Hermanns and Alma Zernecke},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 11},
  pages={2316-25}
}
OBJECTIVE Although immune responses drive the pathogenesis of atherosclerosis, mechanisms that control antigen-presenting cell (APC)-mediated immune activation in atherosclerosis remain elusive. We here investigated the function of hypoxia-inducible factor (HIF)-1α in APCs in atherosclerosis. APPROACH AND RESULTS We found upregulated HIF1α expression in CD11c(+) APCs within atherosclerotic plaques of low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice. Conditional deletion of Hif1a in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

A system for cre - regulated rna interference in vivo

  • S Kissler, P Stern, K Takahashi, K Hunter, LB Peterson, LS Wicker
  • Proc Natl Acad Sci U S A
  • 2008

Protective role of cxc receptor 4 / cxc ligand 12 unveils the importance of neutrophils in atherosclerosis

  • JC Sluimer, JM Gasc, +9 authors AP Bijnens
  • Circ Res
  • 2008

- mediated inflammation

  • C Weber, S Meiler, Y Doring
  • 2003

Similar Papers

Loading similar papers…