Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.

@article{Luo2013DeficiencyOG,
  title={Deficiency of GRP94 in the hematopoietic system alters proliferation regulators in hematopoietic stem cells.},
  author={Biquan Luo and Chun-Chih Tseng and Gregor B. Adams and Amy Si-Ying Lee},
  journal={Stem cells and development},
  year={2013},
  volume={22 23},
  pages={3062-73}
}
We have previously reported that acute inducible knockout of the endoplasmic reticulum chaperone GRP94 led to an expansion of the hematopoietic stem and progenitor cell pool. Here, we investigated the effectors and mechanisms for this phenomenon. We observed an increase in AKT activation in freshly isolated GRP94-null HSC-enriched Lin(-) Sca-1(+) c-Kit(+) (LSK) cells, corresponding with higher production of PI(3,4,5)P3, indicative of PI3K activation. Treatment of GRP94-null LSK cells with the… CONTINUE READING
5 Citations
60 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 60 references

sential roles of grp 94 in gut homeostasis via chaperoning canonical Wnt pathway

  • B Liu
  • Proc Natl Acad Sci U S A
  • 2013

Similar Papers

Loading similar papers…