Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia

@inproceedings{Liu2013DeficiencyOC,
  title={Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia},
  author={Yunmeng Liu and Shelly Y Lensing and Yaping Yan and Todd Michael Cooper and Mignon L Loh and Peter D Emanuel},
  booktitle={Leukemia},
  year={2013}
}
Juvenile myelomonocytic leukemia (JMML) is a rare leukemia of infancy and early childhood. A hallmark of JMML is that JMML cells are selectively hypersensitive to GM-CSF in vitro, but have normal sensitivity to IL-3, which shares the β-subunit receptor with GM-CSF.1, 2 The pathogenesis of JMML is linked to dysregulated signal transduction through the Ras signaling pathway caused by mutations of RAS, PTPN11 and c-CBL, or loss-of-heterozygosity of NF1.3, 4 Although most patients with JMML… CONTINUE READING
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MiRNA Dysregulation in Childhood Hematological Cancer

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  • 2018
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