Deficiency of Bloom's syndrome protein causes hypersensitivity of C. elegans to ionizing radiation but not to UV radiation, and induces p53-dependent physiological apoptosis.

@article{Kim2005DeficiencyOB,
  title={Deficiency of Bloom's syndrome protein causes hypersensitivity of C. elegans to ionizing radiation but not to UV radiation, and induces p53-dependent physiological apoptosis.},
  author={Yun Mi Kim and Insil Yang and Jiyeung Lee and Hyeon-Sook Koo},
  journal={Molecules and cells},
  year={2005},
  volume={20 2},
  pages={228-34}
}
Caenorhabditis elegans him-6 mutants, which show a high incidence of males and partial embryonic lethality, are defective in the orthologue of human Bloom's syndrome protein (BLM). When strain him-6(e1104) containing a missense him-6 mutation was irradiated with gamma-rays during germ cell development or embryogenesis, embryonic lethality was higher than in… CONTINUE READING