Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome.

@article{Qian2008DeficiencyOA,
  title={Deficiency of Act1, a critical modulator of B cell function, leads to development of Sj{\"o}gren's syndrome.},
  author={Youcun Qian and Natalia V. Giltiay and Jianhua Xiao and Yue Wang and Jun Tian and Shuhua Han and Martin T Scott and Robert E. Carter and Trine N. Jorgensen and Xiaoxia Li},
  journal={European journal of immunology},
  year={2008},
  volume={38 8},
  pages={2219-28}
}
CD40L and B lymphocyte-activating factor (BAFF), members of the TNF superfamily, play critical roles in B cell survival and activation, and in the regulation of humoral immunity. We previously reported that the adaptor molecule Act1 functions as a negative regulator of CD40- and BAFF-mediated B cell survival. Here we demonstrated that mice deficient in Act1 developed systemic autoimmune disease with histological and serological features of human Sjögren's syndrome (SS), in association with… CONTINUE READING