Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress.

@article{RamosCastaeda2005DeficiencyOA,
  title={Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress.},
  author={Jose Ramos-Casta{\~n}eda and Young-nam Park and Ming Liu and Karin Hauser and Hans Rudolph and Gary E. Shull and Marcel F. Jonkman and Kazutoshi Mori and Shigaku Ikeda and Hideoki Ogawa and Peter Arvan},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 10},
  pages={9467-73}
}
Relatively few clues have been uncovered to elucidate the cell biological role(s) of mammalian ATP2C1 encoding an inwardly directed secretory pathway Ca2+/Mn2+ pump that is ubiquitously expressed. Deficiency of ATP2C1 results in a human disease (Hailey-Hailey), which primarily affects keratinocytes. ATP2C1-encoded protein is detected in the Golgi complex in a calcium-dependent manner. A small interfering RNA causes knockdown of ATP2C1 expression, resulting in defects in both post-translational… CONTINUE READING

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