Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.

  title={Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain.},
  author={Veronica Hirsch-Reinshagen and Steven Zhou and Braydon L. Burgess and Lise Bernier and Sean A. McIsaac and J. T. Y. Chan and Gavin H K Tansley and Jeffrey S. Cohn and Michael R. Hayden and Cheryl L Wellington},
  journal={The Journal of biological chemistry},
  volume={279 39},
ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside the central nervous system (CNS), ABCA1 functions in the biogenesis of high-density lipoprotein (HDL), where it mediates the efflux of cholesterol and phospholipids to apolipoprotein (apo) A-I. Deficiency of ABCA1 results in lack of circulating HDL and greatly reduced levels of apoA-I. ABCA1 is also expressed in cells within the CNS, but its roles in brain lipid metabolism are not yet fully understood. In… CONTINUE READING
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