Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.

@article{Tian2016DeficiencyIT,
  title={Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke.},
  author={Dai-Shi Tian and Chun-yu Richard Li and Chuan Qin and Madhuvika Murugan and Long-Jun Wu and Jun-Li Liu},
  journal={Journal of neurochemistry},
  year={2016},
  volume={139 1},
  pages={
          96-105
        }
}
Microglia become activated during cerebral ischemia and exert pro-inflammatory or anti-inflammatory role dependent of microglial polarization. NADPH oxidase (NOX)-dependent reactive oxygen species (ROS) production in microglia plays an important role in neuronal damage after ischemic stroke. Recently, NOX and ROS are consistently reported to participate in the microglial activation and polarization; NOX2 inhibition or suppression of ROS production are shown to shift the microglial polarization… CONTINUE READING
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