Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep

@article{Tafti2003DeficiencyIS,
  title={Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep},
  author={Mehdi Tafti and Brice Petit and Didier Chollet and Elisabeth Neidhart and Fabienne de Bilbao and Jozsef Z. Kiss and Philip A. Wood and Paul Franken},
  journal={Nature Genetics},
  year={2003},
  volume={34},
  pages={320-325}
}
In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates… CONTINUE READING