Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice

@article{Hannibal2017DeficiencyIP,
  title={Deficiency in plasmacytoid dendritic cells and type I interferon signalling prevents diet-induced obesity and insulin resistance in mice},
  author={Tine Dahlbaek Hannibal and Anja Schmidt-Christensen and Julia Nilsson and Nina Frans{\'e}n-Pettersson and Lisbeth Hansen and Dan Holmberg},
  journal={Diabetologia},
  year={2017},
  volume={60},
  pages={2033-2041}
}
Obesity is associated with glucose intolerance and insulin resistance and is closely linked to the increasing prevalence of type 2 diabetes. In mouse models of diet-induced obesity (DIO) and type 2 diabetes, an increased fat intake results in adipose tissue expansion and the secretion of proinflammatory cytokines. The innate immune system not only plays a… CONTINUE READING